Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 16 Researches
7.5
USERS' SCORE
Good
Based on 253 Reviews
8.1
Supplement Facts
Serving Size: 1 Capsule
Amount Per Serving
%DV
Milk Thistle Seed 30:1 Extract(Silybum marianum) (Fruit/Seed) (80% [120 mg] Total Flavonoids)
150 mg
†
Top Medical Research Studies
9
We investigated the effects of silymarin on liver and heart health under oxidative stress from paracetamol. In a controlled study with 28 male mice, silymarin showed a strong potential to reduce liver injury markers and improve liver enzyme levels after treatment.
Histopathological assessments revealed less tissue damage and inflammation in mice treated with silymarin compared to those that only received paracetamol. Overall, these findings demonstrate that silymarin is a promising option to help protect the liver and heart from oxidative stress-related injury.
Histopathological assessments revealed less tissue damage and inflammation in mice treated with silymarin compared to those that only received paracetamol. Overall, these findings demonstrate that silymarin is a promising option to help protect the liver and heart from oxidative stress-related injury.
Read More
8
We explored how silybin A, a key ingredient from silybum marianum, impacts liver health. Through studies on liver cells and mice, we discovered that silybin A effectively lowers triglyceride levels while boosting essential phospholipids, supporting a healthy lipid balance.
Our findings suggest that silybin offers protective benefits against liver damage, particularly in cases of mild metabolic imbalance. However, its effectiveness seems limited in more severe liver disease scenarios, highlighting the nuances of its liver-protective properties.
Our findings suggest that silybin offers protective benefits against liver damage, particularly in cases of mild metabolic imbalance. However, its effectiveness seems limited in more severe liver disease scenarios, highlighting the nuances of its liver-protective properties.
Read More
8
Silymarin showed enhanced liver protection
We explored how different forms of silymarin, derived from milk thistle seeds, affect liver health in older hens. In a study with 70 hens, various treatments were given over 12 weeks, including control groups.
We found that higher doses of nano-silymarin and lecithinized silymarin showed significant benefits, such as improved liver enzyme activity and decreased fatty liver symptoms. However, silymarin was less effective at lower doses, which indicates that careful dosing is crucial for optimal results in managing liver issues.
We found that higher doses of nano-silymarin and lecithinized silymarin showed significant benefits, such as improved liver enzyme activity and decreased fatty liver symptoms. However, silymarin was less effective at lower doses, which indicates that careful dosing is crucial for optimal results in managing liver issues.
Read More
Most Useful Reviews
9
Liver health improvement
338 people found this helpful
Milk thistle is highly effective for healing liver cells and detoxifying the body. It aids in cleansing blood vessels and alleviates constipation. I find that it assists with liver disease, dysbiosis, and other issues. I take it for 2-3 months biannually, and it significantly enhances my well-being. The dosage is also favourable.
Read More
7.5
Liver normalization success
237 people found this helpful
This is an excellent remedy for normalising liver function. I am thoroughly satisfied with the results, as my morning sickness from bile stagnation has resolved, greatly improving my overall health. I would recommend it for treating liver disease.
Read More
10
Fatty liver recovery
211 people found this helpful
Milk thistle is a powerful natural detox product for the liver. After being diagnosed with fatty liver disease, I changed my diet and started with 1 capsule daily, increasing to 3. Within 5 weeks, my liver returned to normal.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 16 Researches
7.5
- All Researches
9
We investigated the effects of silymarin on liver and heart health under oxidative stress from paracetamol. In a controlled study with 28 male mice, silymarin showed a strong potential to reduce liver injury markers and improve liver enzyme levels after treatment.
Histopathological assessments revealed less tissue damage and inflammation in mice treated with silymarin compared to those that only received paracetamol. Overall, these findings demonstrate that silymarin is a promising option to help protect the liver and heart from oxidative stress-related injury.
Histopathological assessments revealed less tissue damage and inflammation in mice treated with silymarin compared to those that only received paracetamol. Overall, these findings demonstrate that silymarin is a promising option to help protect the liver and heart from oxidative stress-related injury.
Read More
9
Silymarin improves liver health in mice
We investigated how silymarin, along with other natural compounds, affects non-alcoholic fatty liver disease (NAFLD) in mice. Over 16 weeks, mice on a high-fat diet received silymarin supplements, which significantly improved liver health and reduced fat buildup.
Notably, these changes were linked to beneficial shifts in gut bacteria and their metabolites. The study shows that silymarin may play a key role in enhancing liver function through its positive influence on gut microbiota, offering promising insights for NAFLD treatment.
Notably, these changes were linked to beneficial shifts in gut bacteria and their metabolites. The study shows that silymarin may play a key role in enhancing liver function through its positive influence on gut microbiota, offering promising insights for NAFLD treatment.
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9
We investigated the potential of a specially formulated version of Silybum marianum, known as nano-SM, to combat liver damage caused by a compound called 17α-ethinylestradiol (EE).
In an experiment involving female rats, we discovered that nano-SM significantly reduced harmful liver enzymes and improved antioxidant levels compared to untreated rats.
This suggests that nano-SM could effectively protect the liver from cholestasis-related injury by enhancing the removal of bile acids and reducing inflammation.
In an experiment involving female rats, we discovered that nano-SM significantly reduced harmful liver enzymes and improved antioxidant levels compared to untreated rats.
This suggests that nano-SM could effectively protect the liver from cholestasis-related injury by enhancing the removal of bile acids and reducing inflammation.
Read More
8
We explored how silybin A, a key ingredient from silybum marianum, impacts liver health. Through studies on liver cells and mice, we discovered that silybin A effectively lowers triglyceride levels while boosting essential phospholipids, supporting a healthy lipid balance.
Our findings suggest that silybin offers protective benefits against liver damage, particularly in cases of mild metabolic imbalance. However, its effectiveness seems limited in more severe liver disease scenarios, highlighting the nuances of its liver-protective properties.
Our findings suggest that silybin offers protective benefits against liver damage, particularly in cases of mild metabolic imbalance. However, its effectiveness seems limited in more severe liver disease scenarios, highlighting the nuances of its liver-protective properties.
Read More
8
Silybum marianum aids liver health
We conducted a randomized, double-blind trial to explore the impact of a Silybum marianum (SM) and alpha-lipoic acid (ALA) formulation, combined with a Mediterranean diet, on liver health in those with metabolic dysfunction-associated steatosis.
Our findings showed that this combination can successfully reduce visceral fat and liver fat content over 24 weeks.
Although some patients experienced mild side effects, both treatment and control groups had similar results in this regard. Ultimately, SM-ALA alongside a Mediterranean diet may bring significant benefits to managing liver damage associated with metabolic disorders.
Our findings showed that this combination can successfully reduce visceral fat and liver fat content over 24 weeks.
Although some patients experienced mild side effects, both treatment and control groups had similar results in this regard. Ultimately, SM-ALA alongside a Mediterranean diet may bring significant benefits to managing liver damage associated with metabolic disorders.
Read More
User Reviews
USERS' SCORE
Good
Based on 253 Reviews
8.1
- All Reviews
- Positive Reviews
- Negative Reviews
9
Liver health improvement
338 people found this helpful
Milk thistle is highly effective for healing liver cells and detoxifying the body. It aids in cleansing blood vessels and alleviates constipation. I find that it assists with liver disease, dysbiosis, and other issues. I take it for 2-3 months biannually, and it significantly enhances my well-being. The dosage is also favourable.
Read More
7.5
Liver normalization success
237 people found this helpful
This is an excellent remedy for normalising liver function. I am thoroughly satisfied with the results, as my morning sickness from bile stagnation has resolved, greatly improving my overall health. I would recommend it for treating liver disease.
Read More
10
Fatty liver recovery
211 people found this helpful
Milk thistle is a powerful natural detox product for the liver. After being diagnosed with fatty liver disease, I changed my diet and started with 1 capsule daily, increasing to 3. Within 5 weeks, my liver returned to normal.
Read More
9
Liver support effectiveness
136 people found this helpful
The ingredients are excellent. Milk thistle is beneficial for liver health, especially regarding liver disease.
Read More
9
Restores liver function
57 people found this helpful
Instead of feedback, I share my subscriber's test results after I advised them to take milk thistle and prescribed a health stack. I recommend this substance for anyone with liver disease as it aids in restoring an already damaged liver. Thank you all.
Read More
Frequently Asked Questions
10
Fatty liver recovery
211 people found this helpful
Milk thistle is a powerful natural detox product for the liver. After being diagnosed with fatty liver disease, I changed my diet and started with 1 capsule daily, increasing to 3. Within 5 weeks, my liver returned to normal.
9
Liver enzymes normal
6 people found this helpful
It truly works for liver disease! I am diabetic and had elevated liver enzymes. After about eight months of taking milk thistle, my liver enzymes are now normal. I believe this improvement is due to milk thistle, and it's an affordable product that I'll continue using for life.
10
Normal liver function
5 people found this helpful
Jarrow FORMULAS Milk Thistle is an effective natural liver detox product. After switching to a healthy diet and taking this supplement, my liver returned to normal.
7.5
Liver normalization success
237 people found this helpful
This is an excellent remedy for normalising liver function. I am thoroughly satisfied with the results, as my morning sickness from bile stagnation has resolved, greatly improving my overall health. I would recommend it for treating liver disease.
9
Reduced stomach pain
7 people found this helpful
Best of all, it resolved my right side aches in my stomach. After photography, I found I have liver disease. After a week of use, the pain in my liver has diminished, and I feel better; even my tinnitus lessens. I no longer experience fatigue and can arise at 5 am for prayer without concern.
9
Supports liver health
53 people found this helpful
My husband and I take milk thistle twice a year to support our liver health. It is considered the top liver protector. Taking one capsule daily has improved bile production and digestive functions without any side effects. Please like if you find this helpful.
9
Restores liver function
57 people found this helpful
Instead of feedback, I share my subscriber's test results after I advised them to take milk thistle and prescribed a health stack. I recommend this substance for anyone with liver disease as it aids in restoring an already damaged liver. Thank you all.
9
Supports digestion
8 people found this helpful
On my nutritionist's advice, I take milk thistle with food to support my liver and gallbladder functions. It effectively improves fat digestion without causing issues.
9
High-quality protection
26 people found this helpful
I've relied on milk thistle extract from Jarrow for years while on liver-affecting medications. Despite my intensive regime, I maintain excellent liver health as per my doctor's checks.
9
Powerful liver properties
5 people found this helpful
Milk thistle is renowned for its medicinal properties, particularly for liver disease. We take 1-2 capsules daily; if feeling unwell, 3. It works well as a liver detoxifier.
8
We explored the role of silymarin, a compound from milk thistle, as an antioxidant treatment for chronic liver diseases like hepatitis and cirrhosis. Through a thorough review of clinical studies, we found that silymarin shows promise for protecting the liver and may help improve liver function in patients with these conditions.
However, while the results are hopeful, more research is necessary to determine the best dosage, long-term safety, and potential interactions with other medications. This review highlights silymarin's potential and sets the stage for future research on its clinical application.
However, while the results are hopeful, more research is necessary to determine the best dosage, long-term safety, and potential interactions with other medications. This review highlights silymarin's potential and sets the stage for future research on its clinical application.
7
We systematically reviewed 29 randomized clinical trials to explore the impact of silymarin, derived from milk thistle, on liver enzyme levels. While many studies showed promising reductions in liver enzymes, some reported no significant changes or even increases.
About 65.5% of the studies indicated that silymarin could be beneficial, especially for those with non-alcoholic fatty liver disease. However, results varied based on patient conditions and dosage, highlighting the need for further research on optimal use.
About 65.5% of the studies indicated that silymarin could be beneficial, especially for those with non-alcoholic fatty liver disease. However, results varied based on patient conditions and dosage, highlighting the need for further research on optimal use.
8
Silybum marianum aids liver health
We conducted a randomized, double-blind trial to explore the impact of a Silybum marianum (SM) and alpha-lipoic acid (ALA) formulation, combined with a Mediterranean diet, on liver health in those with metabolic dysfunction-associated steatosis.
Our findings showed that this combination can successfully reduce visceral fat and liver fat content over 24 weeks.
Although some patients experienced mild side effects, both treatment and control groups had similar results in this regard. Ultimately, SM-ALA alongside a Mediterranean diet may bring significant benefits to managing liver damage associated with metabolic disorders.
Our findings showed that this combination can successfully reduce visceral fat and liver fat content over 24 weeks.
Although some patients experienced mild side effects, both treatment and control groups had similar results in this regard. Ultimately, SM-ALA alongside a Mediterranean diet may bring significant benefits to managing liver damage associated with metabolic disorders.
7
Silybum marianum shows potential benefits
We conducted a randomized, triple-blind, placebo-controlled trial to explore the effects of tablets containing Silybum marianum and other herbal ingredients on non-alcoholic fatty liver disease (NAFLD) in adults.
Involving 121 patients over 24 weeks, the study compared the effects of SPS tablets against a placebo. While the results indicated potential benefits for those taking SPS, particularly in reducing liver fat, we found that more extensive research is needed to firmly establish these effects.
Overall, the findings are promising, but the journey to understanding the full impact of silymarin continues.
Involving 121 patients over 24 weeks, the study compared the effects of SPS tablets against a placebo. While the results indicated potential benefits for those taking SPS, particularly in reducing liver fat, we found that more extensive research is needed to firmly establish these effects.
Overall, the findings are promising, but the journey to understanding the full impact of silymarin continues.
References
- Koeberle SC, Thürmer M, Su F, Werner M, Grander J, et al. Silybin A from reprograms lipid metabolism to induce a cell fate-dependent class switch from triglycerides to phospholipids. Theranostics. 2025;15:2006. 10.7150/thno.99562
- Cano Contreras AD, Del Rocío Francisco M, Vargas Basurto JL, Gonzalez-Gomez KD, Amieva-Balmori M, et al. Effect of alpha-lipoic acid and supplementation with a Mediterranean diet on metabolic dysfunction-associated steatosis. World J Hepatol. 2025;17:101704. 10.4254/wjh.v17.i1.101704
- Shaker MK, Hassany M, Eysa B, Adel A, Zidan A, et al. The activity of a herbal medicinal product of Phyllanthus niruri and Silybum marianum powdered extracts (Heptex®) in patients with apparent risk factors for nonalcoholic steatohepatitis: a phase II, multicentered, randomized, double-blind, placebo-controlled clinical trial. BMC Complement Med Ther. 2025;25:8. 10.1186/s12906-024-04692-y
- Selc M, Macova R, Babelova A. Novel Strategies Enhancing Bioavailability and Therapeutical Potential of Silibinin for Treatment of Liver Disorders. Drug Des Devel Ther. 2024;18:4629. 10.2147/DDDT.S483140
- Faryadi S, Sheikhahmadi A, Farhadi A, Nourbakhsh H. Evaluating the therapeutic effect of different forms of silymarin on liver status and expression of some genes involved in fat metabolism, antioxidants and anti-inflammatory in older laying hens. Vet Med Sci. 2024;10:e70025. 10.1002/vms3.70025
- Dhande D, Dhok A, Anjankar A, Nagpure S. Silymarin as an Antioxidant Therapy in Chronic Liver Diseases: A Comprehensive Review. Cureus. 2024;16:e67083. 10.7759/cureus.67083
- Li BY, Xi Y, Liu YP, Wang D, Wang C, et al. Effects of Silybum marianum, Pueraria lobate, combined with Salvia miltiorrhiza tablets on non-alcoholic fatty liver disease in adults: A triple-blind, randomized, placebo-controlled clinical trial. Clin Nutr ESPEN. 2024;63:2. 10.1016/j.clnesp.2024.06.003
- Jaffar HM, Al-Asmari F, Khan FA, Rahim MA, Zongo E. Silymarin: Unveiling its pharmacological spectrum and therapeutic potential in liver diseases-A comprehensive narrative review. Food Sci Nutr. 2024;12:3097. 10.1002/fsn3.4010
- Okiljević B, Martić N, Govedarica S, Andrejić Višnjić B, Bosanac M, et al. Cardioprotective and Hepatoprotective Potential of Silymarin in Paracetamol-Induced Oxidative Stress. Pharmaceutics. 2024;16. 10.3390/pharmaceutics16040520
- Wang X, Jin Y, Di C, Zeng Y, Zhou Y, et al. Supplementation of Silymarin Alone or in Combination with Salvianolic Acids B and Puerarin Regulates Gut Microbiota and Its Metabolism to Improve High-Fat Diet-Induced NAFLD in Mice. Nutrients. 2024;16. 10.3390/nu16081169
- Salem MB, Mohammed DM, Hammam OA, Elzallat M. Mitigation of intrahepatic cholestasis induced by 17α-ethinylestradiol via nanoformulation of Silybum marianum L. BMC Complement Med Ther. 2024;24:51. 10.1186/s12906-024-04351-2
- Singla RK, Singh D, Verma R, Kaushik D, Echeverría J, et al. Fermented formulation of Silybum marianum seeds: Optimization, heavy metal analysis, and hepatoprotective assessment. Phytomedicine. 2024;124:155286. 10.1016/j.phymed.2023.155286
- Calderon Martinez E, Herrera D, Mogan S, Hameed Z, Jangda AA, et al. Impact of Silymarin Supplements on Liver Enzyme Levels: A Systematic Review. Cureus. 2023;15:e47608. 10.7759/cureus.47608
- Ma X, Yu X, Li R, Cui J, Yu H, et al. Berberine-silybin salt achieves improved anti-nonalcoholic fatty liver disease effect through regulating lipid metabolism. J Ethnopharmacol. 2024;319:117238. 10.1016/j.jep.2023.117238
- Talebi A, Soltani R, Khorvash F, Jouabadi SM. The Effectiveness of Silymarin in the Prevention of Anti-tuberculosis Drug-induced Hepatotoxicity: A Randomized Controlled Clinical Trial. Int J Prev Med. 2023;14:48. 10.4103/ijpvm.ijpvm_81_22
- Ghodousi M, Karbasforooshan H, Arabi L, Elyasi S. Silymarin as a preventive or therapeutic measure for chemotherapy and radiotherapy-induced adverse reactions: a comprehensive review of preclinical and clinical data. Eur J Clin Pharmacol. 2023;79:15. 10.1007/s00228-022-03434-8
